Endocrine Abstracts

Objective: Rosacea is an inflammatory dermatosis. Telangiectasias, edema, erythema, and acneiform eruptions are the main symptoms. Several genetic and environmental factors have been linked to rosacea; however, the etiology of the disease is still not known. It is considered a systemic disease rather than a skin disorder. Endocrine-disrupting chemicals are substances people are exposed to through water, food, self-care products, and the environment. They interfere with normal ...

Introduction: CNC (Carney complex) is a rare inherited autosomal dominant syndrome characterized by prominent pigmented lesions on the skin and mucosal surfaces, cardiac and noncardiac myxomatous tumors, and multiple endocrine neoplasms. About 70% of cases have a family history, while the remaining 30% occur sporadically as a result of de novo mutation. Two genetic loci linked to CNC have been found: the CNC1 gene on chromosome 17q22-24, which encodes the regulatory subunit (R...

Introduction: Fahr disease, is a rare pathology characterized by neuropsychiatric symptoms and bilateral symmetrical intracranial, especially basal ganglial calcifications. Although the exact etiology is not known, it is often associated with calcium and phosphorus metabolism disorders. We aim to present two brothers who presented with Fahr’s disease which is a rare condition.Case: Sixty-year-old male patient without a medical history of ilness was ...

Purpose: Irisin is a secreted protein implicated in the regulation of insulin sensitivity and energy metabolism. Polycystic ovary syndrome (PCOS) is an inflammatory-based metabolic disease associated with insulin resistance, dyslipidemia, glucose metabolism dysfunction and obesity. There is also some evidence of a link between irisin and inflammation. Our aim of the study to ascertain whether the association of circulating irisin levels with inflammatory markers in PCOS.<p...

Hashimoto’s thyroiditis is thought to result from the decreased of T helper type 2 (Th2) responses, leading to progressive destruction of thyrocytes. IFN-λ1, -λ2, and -λ3 (also known as IL-29, IL-28A, and IL-28B, respectively) is a recently described member of the IFN-λ family and has been shown to decrease production of Th2 cytokines in vitro. However, the role and mechanism of IFN-λ1 in Hashimoto’s thyroiditis remain unkno...

Objective: Aspergillosis is defined as the infection of the Aspergillus type mold and is commonly seen in hematologic malignancies, hematopoietic stem cell transplantation, aplastic anemia, primary immunodeficiency, and immunocompromised patients. Fungal sinusitis in diabetes mellitus is generally presented as rhinoorbitocerebral involvement of mucormycosis. Herein, a fungal sinusitis caused by Aspergillus case presented with headache is reported.<p class...

Background and aims: Neuropeptide Y (NPY) cause decrease glomerular filtration rate, aldosterone concentration, and plasma renin activity by stimulating NPY receptors in the kidney. Previous studies have suggested that NPY polymorphism is related to development of advanced diabetic nephropathy (DN). The aim of this study was to evaluate the relationship between the serum neuropeptide Y levels and different stages of DN in patients with type 2 diabetes mellitus (T2DM).<p cl...

Introduction: Association between ankle-brachial index (ABI) and coronary, cerebral, and peripheral vessels involvement has been shown in different studies. The normal range of ABI is between 0.9 and 1.4. Values below 0.9 show peripheral vessel disease. An ABI more than 1.4 is characteristic for vascular rigidity. We aimed to investigate the ABI value in our type 2 diabetic patients and association of ABI with glycemic control.Materials and methods: This...

Background and aims: Orexins are hypothalamic neuropeptides involved in energy homeostasis and sleep regulation. We aimed to find the relation between serum orexin-A levels, glucose, and insulin levels, depression and sleep problems in patients with metabolic syndrome.Materials and methods: This descriptive, cross-sectional study included 43 patients with metabolic syndrome (patient) and 16 healthy subjects (control, age, and sex matched) who applied to ...

Thyroid cancer in Turkey is the most common endocrine neoplasm with an incidence of 3.7%. Papillary thyroid carcinoma is the most common thyroid malignancy in a similar manner. Papillary thyroid carcinoma creates 50–90% of differentiated thyroid carcinomas. There is available in subgroups with poor prognosis. Case-specific mortality of 2% at 5, 10, and 20 years, only 4 and 5%.Mutations and re-arrangements in genes encoding proteins of the MAPK pathw...